OVERALL SUMMARY/ABSTRACT OF THE PARENT GRANT The UCLA Clinical and Translational Science Institute is a research partnership of the University of California Los Angeles, Cedars-Sinai Medical Center, Charles R. Drew University of Medicine and Science and the Harbor- UCLA Medical Center/ Lundquist Institute for Biomedical Innovation. Our mission is to bring biomedical innovations to bear on the greatest health needs of Los Angeles, an ethnically and economically diverse metropolis of more than 10 million people. In the past 10 years, we have built a robust research infrastructure to support our mission. In partnership with the community, we have made important advances against the leading causes of preventable disability and death. Supporting these advances is a streamlined regulatory infrastructure. We have instituted scientific review, reduced time-to-study-activation by 42%, and achieved 100% compliance with ClinicalTrials.Gov. As we enter our next decade, we are building on our progress by augmenting the integration with our institutional hub partners and broadening collaborations in the community as well as with investigators outside the health professions. Because Equity, Diversity and Inclusion (EDI) is a foundational principle of our CTSI, we have embarked on an Inclusive Science Initiative, led by our EDI Senior Associate Director, to ensure that our research and training programs continue to embrace this guiding principle. Through new T1-T4 seminars and team science trainings and opportunities, we are equipping our trainees to conduct multidisciplinary team science across the translational spectrum. We are systematically evaluating our CTSI outcomes and overall impact. The UCLA CTSI has five specific aims: 1) Enhance education and training to prepare and expand the translational workforce, 2) Engage stakeholder communities in multidisciplinary team science and disseminate successful models of collaboration, 3) Integrate special populations, including those experiencing health disparities, into translational research, 4) Improve methods and processes to accelerate efficient, high-quality, multisite research, and 5) Provide informatics solutions to advance high-impact translational science.