# Clinician Scientist in Leukemia

> **NIH NIH R50** · WASHINGTON UNIVERSITY · 2024 · $132,781

## Abstract

PROJECT SUMMARY / ABSTRACT
This project is intended to support the applicant as a clinician-scientist in leukemia at Washington University
School of Medicine / Siteman Cancer Center supporting NCI-funded clinical research. As Medical Director for
Clinical Research, the applicant will support the implementation of clinical research at the institution by 1)
improving operational efficiency, 2) expanding program capabilities, and 3) ensuring protocol compliance to
achieve the highest quality conduct of clinical trials that can improve the lives of patients with cancer.
The applicant will also provide scientific leadership to NCI-funded research as co-chair of the Leukemia
Committee of the Alliance for Clinical Trials in Oncology and the Older AML Clinical Basket for myeloMATCH,
the NCI Precision Medicine Initiative in myeloid malignancies. The Leukemia Committee of the Alliance will
continue to conduct practice-changing treatment trials and further our understanding of the biological basis of
leukemia and its treatment. In addition, the Committee will address health disparities in leukemia by increasing
the accrual of underrepresented minorities and assessing the impact of social determinants of health.
In older adults with AML, myeloMATCH will test the combination of targeted therapies with hypomethylating
agents and venetoclax to improve remission rates and validate the prognostic significance of flow cytometry-
based measurable residual disease. A companion geriatric assessment will be implemented across treatment
studies to validate measures that predict treatment tolerance and benefit.

## Key facts

- **NIH application ID:** 10930806
- **Project number:** 5R50CA275927-02
- **Recipient organization:** WASHINGTON UNIVERSITY
- **Principal Investigator:** GEOFFREY L UY
- **Activity code:** R50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $132,781
- **Award type:** 5
- **Project period:** 2023-09-18 → 2028-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10930806

## Citation

> US National Institutes of Health, RePORTER application 10930806, Clinician Scientist in Leukemia (5R50CA275927-02). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10930806. Licensed CC0.

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