PROJECT ABSTRACT – ANALYSIS AND RAPID RESPONSE CORE The principal goal of the Analysis and Rapid Response Core (ARRC) is to serve as a central scientific hub to foster rapid, responsive, and rigorous collaborative tobacco regulatory science (TRS) and provide methodological and analytic expertise to expedite TRS research pertinent to the Center for Tobacco Product's (CTP's) regulatory mission. The ARRC will promote the use of common measures, protocols, and terminology and provide support for data harmonization and sharing. CASEL's central coordinating role in TRS research provides us with an informed vantage, “big picture” view of the TRS research portfolio and its investigators, facilitating the ability to identify opportunities for coordination, collaboration, and synthesis of research among the Tobacco Centers of Regulatory Science (TCORS) and other CTP-funded grantees, as well as surveillance projects such as the Center for Rapid Surveillance of Tobacco (CRST) and the Population Assessment of Tobacco and Health (PATH) Study. The result of these efforts will be collaborative, coordinated, and synergistic TRS research that is robust and optimizes impact. Under the leadership of Dr. Cassandra Stanton (proposed as ARRC Lead), We will build on the work of CECTR and CASEL 1.0 to use the tools and processes developed to keep pace with the changing landscape, and we will work with our Federal partners to identify and respond to research priorities and needs. We will continue to provide rapid response to analytic needs through training, resource development, and consultation to advance methodological rigor to address time-sensitive and critical research questions. We are also well-positioned to deliver efficient management of the new Opportunity Fund (OF) program to award funds to innovative research projects.