# Identifying risk earlier: Prenatal exposures, neurodevelopment, and infant sleep as pathways to toddler attention and behavior dysregulation

> **NIH NIH R01** · UNIVERSITY OF OREGON · 2024 · $795,396

## Abstract

PROJECT SUMMARY/ABSTRACT
Early attention and behavior dysregulation are developmental precursors to later disruptive behavior disorders,
one of the major categories of childhood psychopathology. Recent conceptualizations of child behavior disorders
classify these diagnoses as neurodevelopmental conditions, which suggests unexplored prenatal and early life
origins. The proposed study will test the premise that child behavior dysregulation emerges, in part, from prenatal
exposures to disrupted maternal sleep and emotion dysregulation—a transdiagnostic indicator of
psychopathology. Data from our laboratories provide evidence that exposure to maternal emotion dysregulation
associates with neurodevelopmental differences in newborn arousal and attention, as measured within hours
after birth. Additional pilot analyses reveal that this blunted neurodevelopmental profile associates with behavior
problems at 18 months. A goal of this study is to explore whether early sleep difficulties function as a behavioral
mechanism connecting infant neurodevelopmental profiles to toddler attention and behavior dysregulation at 12
months. Sleep is a foundational health behavior and one of the earliest dyadic/family-based regulatory
processes. We propose an innovative design for measuring maternal, paternal, and infant sleep variability,
defined as inconsistency in hours slept per night, using a longitudinal burst design. Sleep will be assessed via
actigraphy and research-validated consumer devices during the 2nd and 3rd trimester, week 1 after birth, then
months 4, 6, 9, and 12. We aim to test whether (1) prenatal exposure to maternal emotion dysregulation,
chronotype, and sleep variability predicts infant neurodevelopment and maternal-infant sleep variability; (2) infant
neurodevelopment interacts with environmental sleep structure (e.g., bedtime routines) to affect infant sleep
variability over time; and (3) infant sleep trajectories characterized by high variability (i.e., failure to attain
normative stability) will mediate associations between neurodevelopmental profiles and toddler attention and
behavior dysregulation. An exploratory aim will incorporate direct and indirect influences of partners on maternal
and infant sleep. To accomplish these innovative aims, we will use established protocols to enroll women in the
2nd trimester of pregnancy (N=200 women) along a uniform distribution of emotion dysregulation, and their
partners. This technique overrepresents women with high dysregulation and increases statistical power. Women,
partners, and infants will then be followed for the first 12 months after birth using techniques that minimize
burden, due to passive monitoring and brief surveys. This study builds upon rigorous prior research, including
work from our own NIH-funded projects, to delve into the crucial challenge of infant sleep. The study unites a
stellar team, with expertise in maternal emotion dysregulation, infant neurodevelopment, adult and infant sle...

## Key facts

- **NIH application ID:** 10930901
- **Project number:** 5R01MH132210-02
- **Recipient organization:** UNIVERSITY OF OREGON
- **Principal Investigator:** Liz D Conradt
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $795,396
- **Award type:** 5
- **Project period:** 2023-09-18 → 2025-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10930901

## Citation

> US National Institutes of Health, RePORTER application 10930901, Identifying risk earlier: Prenatal exposures, neurodevelopment, and infant sleep as pathways to toddler attention and behavior dysregulation (5R01MH132210-02). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10930901. Licensed CC0.

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