Core B: Bioinformatics and Biostatistics Core SUMMARY/ABSTRACT The primary goal of the Bioinformatics and Biostatistics Core is to provide centralized biostatistics, bioinformatics, and database support for all SPORE projects and cores, ranging from basic science studies to animal studies to genomics studies to clinical trials. The Core will serve multiple needs for the planning and conduct of the SPORE's translational research. Based on a strong track record of providing biostatistical support for translational research, the Core will be a comprehensive, multilateral resource for designing clinical and basic science experiments, performing statistical analyses, developing innovative statistical methodology, and publishing the research results generated from the SPORE. The Core will confer regularly with project investigators to discuss the design and conduct of research projects, evaluate results of analyses, discuss potential new research initiatives and directions within the SPORE, and promote the publication of findings. To serve all proposed SPORE Projects, as well as the Career Enhancement and Developmental Research Programs, the Bioinformatics and Biostatistics Core has the following specific aims: Specific Aim 1: Provide statistics and data analyses required for the Projects and Cores to achieve their specific aims; Specific Aim 2: Provide bioinformatics expertise required for analyses and interpretation of high-throughput assay data; Specific Aim 3: Assist with design and implementation of new trials and studies arising from SPORE research; Specific Aim 4: As necessary, to develop and adapt innovative statistical and bioinformatics methods pertinent to ovarian cancer studies.