# Ti-catalyzed cascading hydroaminoalkylation as a route to complex functionalized amines

> **NIH NIH F32** · UNIVERSITY OF MINNESOTA · 2024 · $73,828

## Abstract

Project Summary/Abstract
Central to the development of medicine is organic chemistry and catalysis as it has permitted the
discovery of new reactions and methods for the synthesis of key pharmaceutical components that will
play a critical role in continuing the advancement of modern medicine. With the high presence of
nitrogen atoms in drug candidates due to their high biological activity, it is crucial to develop new and
innovative methods to synthesize and functionalize nitrogen-containing molecules. Recently, reactive
titanium intermediates were used to explore second insertions of unsaturated species yielding useful
nitrogen heterocycles. This proposal will focus on developing an efficient and one-step atom-
economical Ti-catalyzed multicomponent, cascading hydroaminoalkylation reaction to produce β-
cycloalkyl amines from dienes and amine/aniline substrates. This methodology has potential to be a
valuable synthetic tool because β-cycloalkyl amines products are scaffolds present in pharmaceutical
compounds such as cyclopentamine and propylhexedrine and in M3 muscarinic antagonist.
Additionally, this method will provide a fundamental understanding of this new reaction class that can
be extended into other cascading reactions to rapidly build molecule complexity.

## Key facts

- **NIH application ID:** 10931373
- **Project number:** 5F32GM151788-02
- **Recipient organization:** UNIVERSITY OF MINNESOTA
- **Principal Investigator:** Zoua Pa Vang
- **Activity code:** F32 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $73,828
- **Award type:** 5
- **Project period:** 2023-08-18 → 2025-08-17

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10931373

## Citation

> US National Institutes of Health, RePORTER application 10931373, Ti-catalyzed cascading hydroaminoalkylation as a route to complex functionalized amines (5F32GM151788-02). Retrieved via AI Analytics 2026-06-24 from https://api.ai-analytics.org/grant/nih/10931373. Licensed CC0.

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