Abstract Alara Imaging, Inc. (Alara) is seeking funding to support the development of robust, IP-protected, HIPAA- compliant commercial quality software to calculate and report on quality measures that will be reported for every radiologist and hospital group in the nation. Further, Alara is seeking funding to develop enhanced feedback that leverages machine learning, data visualization, and benchmarking to guide physicians and hospitals on safe approaches for lowering their CT radiation doses. Once implemented at scale through the support of this award, Alara’s software has the potential to reduce the cancers that result from CT by up to 30%, preventing as many as 10,000 cancers annually. The use of CT has grown substantially over the last 2 decades with 90 million CT exams performed annually in the U.S. A major quality gap exists in the performance of CT as the radiation doses used for these exams are higher than needed for diagnosis and in the range where they increase a person's risk of developing cancer; it is estimated that CT use causes 36,000 cancers annually in the U.S.1 The inconsistency in how CT exams are performed represents a modifiable health risk as radiation doses can be reduced through audit and feedback, as shown in a UCSF led, NCI funded, trial.2 In 2019, UCSF was awarded a cooperative agreement from CMS to develop CT radiation dose and image quality measures for use in the agency’s pay-for-performance programs. The intent of this award was to motivate radiologists and hospitals and to reduce unnecessarily high radiation doses through financial incentives. UCSF created the approach to judge each CT by combining clinical and radiology data located in disparate health data systems including the Electronic Health Record, Radiology Information System, and Picture Archiving and Communication System. These data systems communicate poorly, and properly ingesting and normalizing these data in real time was a technological challenge. Additionally, as a stipulation of the funding, CMS required UCSF to develop these measures as electronic clinical quality measures (eCQM); however, the resources required to develop and implement an eCQM at the national level were beyond what was available to Dr. Smith-Bindman from CMS. As a result, Dr. Smith-Bindman, in collaboration with UCSF as a minority equity stakeholder, worked with radiology informatics experts to create a commercial entity, Alara, to develop the eCQMs and software for national implementation. The measures are now being considered for use in CMS quality payment programs, and Alara is now seeking funding to implement the measures at scale. In addition to the CMS measure functionality, the software’s architecture will represent a meaningful technological advancement and creates value beyond measure reporting by linking and providing access to combined clinical and radiology data connected to the cloud. Information technology companies that are driving care forward in radiology using ...