# Core 1: Biostatistics & Bioinformatics Core

> **NIH NIH P20** · UNIVERSITY OF HAWAII AT MANOA · 2024 · $231,022

## Abstract

SUMMARY / ABSTRACT
The goal of the Biostatistics and Bioinformatics Core (BBC) is to provide support to the SPORE projects,
other cores, as well as the researchers funded through the Developmental Research Program or Career
Enhancement Program in all aspects of study design and data management, processing, integration and
analysis. This proposal focuses on translational research in minority health and health equity in cancer for the
diverse populations of Hawaii, particularly the understudied Asian American, Native Hawaiian and Pacific
Islander (AANHPI) groups. Project 1 will focus on prevention of hepatocellular carcinoma, for which Hawaii’s
AANHPI populations are at high risk, by evaluating, in a randomized clinical trial, the efficacy of an intermittent
energy restriction on reducing liver fat and liver stiffness in non-alcoholic fatty liver disease (NAFLD) with
predicted fibrosis stage 2+. Project 2 will focus on reducing the disparity for lung cancer among Native Hawaiians
through elucidation of the behavioral aspects of, and improved guidelines for, screening and the biological
characteristics of this malignancy in this population. Project 3 will focus on breast cancer prevention among
AANHPI women through calibration and addition of mammography radiomic features, associated with prognosis
and adiposity, to commonly used breast cancer risk models (e.g., Gail model). The BBC is staffed by a team
experienced in biostatistics and bioinformatics for translational research in multiethnic populations. Provision of
the highest quality support will be facilitated by having the expertise concentrated in the Core rather than in
individual projects, as this will lead to sharing of ideas and tools. The aims of the core are: 1) to provide support
for data management and integration for the projects, while ensuring data quality and security processes are
incorporated, 2) to develop and execute study design and analysis plans for each of the research projects, in
conjunction with Project Leaders, and 3) to facilitate data sharing among SPORE researchers and with the
research community. We will ensure that the most appropriate and rigorous data collection, management and
analysis approaches are used, that the flow of data and material is seamless, and that requirements for data
governance, security, and sharing are met. In addition, we will explore novel techniques, such as integrative
clustering and Bayesian methods for combining omics data, to better understand the underlying mechanisms.
The BBC as a single locus for these comprehensive activities will provide efficiency, integration and scientific
rigor that are not otherwise available.

## Key facts

- **NIH application ID:** 10931604
- **Project number:** 5P20CA275734-02
- **Recipient organization:** UNIVERSITY OF HAWAII AT MANOA
- **Principal Investigator:** LYNNE R WILKENS
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $231,022
- **Award type:** 5
- **Project period:** 2023-09-19 → 2026-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10931604

## Citation

> US National Institutes of Health, RePORTER application 10931604, Core 1: Biostatistics & Bioinformatics Core (5P20CA275734-02). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10931604. Licensed CC0.

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