ABSTRACT The Administrative Core (Admin Core) supports all aspects of the U54 Partnership for the Advancement of Cancer Research between New Mexico State University and Fred Hutchinson Cancer Center. The Partnership’s cancer research, research education, and outreach activities are made possible through efficient program leadership by Dr. Graciela Unguez at NMSU and Dr. Julian Simon at Fred Hutch. Working jointly, Drs. Unguez and Simon have assembled an Admin Core staff including Program Managers (Ms. Lené Löest at NMSU and Ms. Marilyn Drennan at Fred Hutch) with extensive experience managing the Partnership’s budgets, communications, and logistics. The Admin Core benefits from close ties with institutional leadership on both campuses. Partnership programs are administered collaboratively, and, when feasible, in both locations. The 1,653 mile separation between the two campuses has necessitated effective long-distance communication since long before the COVID-19 pandemic. Over the Partnership’s 20-year history, the Admin Core has successfully launched and optimized research, education and outreach programs in New Mexico and Washington State through committed effort to long distance coordination, management, and communication. While the pandemic has impacted in-person activities, the Partnership was able to adapt and redeploy resources to advance programmatic goals. The Admin Core has effectively managed allocation of resources, logistical support for in-person and remote program meetings as well as oversight of planning and evaluation of research, education and outreach efforts while consistently maintaining a high level of productivity, effectiveness and impact. The Admin Core’s support of Partnership activities has enabled progress toward meeting the goal of advancing health equity. Development of the Guiding Principles elaborated in Overall, is a major commitment to meeting that goal.