ABSTRACT The Outreach Core is based on the premise that the US-Mexico border and Indian Country in the northwestern regions of New Mexico (NM), as well as the Central region of Washington State (WA) are largely rural and medically underserved areas where inequities are severe, especially among Hispanic/Latinx, American Indian (AI), and LGBTQAI+ populations. These geographical areas are the foci of the Outreach Core’s work. Long term, the Partnership aspires to increase the health equity in these regions. To do so, the Specific Aims are: 1) To integrate community engagement activities and practices within the Partnership for Advancing Cancer Research (PACR); 2) To increase capacity for community-academic partnerships to successfully use community-based participatory research (CBPR); and 3) To build on and use evidence-based programs (EBPs) to promote cancer equity in Latinx, AI, and LGBTQIA+ populations. The Outreach Core was very successful in the U54-III, reaching 4,631 individuals in NM and 3,287 in WA. Since the outbreak of the COVID-19 pandemic, in-person cancer prevention education and other Outreach Core activities were adapted to online platforms in English and Spanish. At the request of the Community Action Boards (CABs), information on COVID-19 and vaccination was disseminated through social media with positive results. For this U54-IV, we will follow the Partnership Guiding Principles of 1) restructuring scientific environments; 2) restructuring scientific processes; and 3) restructuring scientific engagement, and will work collaboratively with our CABs to foster mutual understanding of the Partnership and the community organizations represented by the CABs to ensure that NMSU and Fred Hutch equitably engage communities in all the activities. CAB discussions about the various Research Projects and Cores will be initiated as well as bi-directional discussions on community-based participatory research (CBPR). The Partnership will also endeavor to establish community organization expertise in research initiatives by providing training and education in research. The expected end result will be community-oriented Pilot and Pre-Pilot projects funded by the Partnership. Five modules fostering inclusion of community members in research practices will provide opportunities for historically marginalized communities to voice their strengths and ways of knowing through collaborative experiences. Finally, the Outreach Core will continue to collaborate with the CABs and communities on evidence-based programs such as Screen-to-Save (a colorectal cancer screening program), Yéego (a Navajo healthy eating project), e-Learning by the Cooperative Extension Services (on healthy lifestyle behaviors), and Cancer 101 (a series on cancer causes, prevention and detection). The Planning & Evaluation Core (P&E Core) will evaluate the formative and summative outcomes of the activities.