PROJECT SUMMARY The Administrative Core provides strong, centralized scientific and administrative leadership to the PPG, which facilitates synergistic interactions between the four projects and two scientific cores and maintains the overall focus of the program project. The Core will coordinate the research mission, monitor timelines for achieving research milestones, coordinate and integrate PPG activities, and implement a plan for regular evaluation of scientific progress. Drs. Chak, Guda, and Garman will be assisted by the Executive Steering Committee (project and core leaders), as well as the Advisory Board, which includes internal and external members. The Administrative Core will oversee annual budgets, monitor expenses and provide monthly statements of financial activities to the projects and scientific cores. In addition, all program-related meetings will be scheduled through the core. These include the weekly meeting of the Executive Steering Committee, monthly Cross-Program Progress Seminars, and the Annual Program Retreat. In addition, generation of materials to be reviewed by the Advisory Board will be handled through the Administrative Core. Finally, the Administrative Core will prepare, generate and assemble materials required for the annual progress reports and will ensure that all additional NIH and institutional reporting requirements concerning PPG activities are fulfilled in a timely manner.