PROJECT SUMMARY/ABSTRACT The Integrative Systems Biology Core will interact with all investigators to develop and apply appropriate analysis methods and designs to most efficiently achieve project goals. We will ensure that the experimental data is analyzed appropriately to test the hypotheses relevant to each project. In addition, the Integrative Systems Biology Core will provide infrastructure and oversight for secure management of all study data, working closely with the Bioreagents & Resource Core to facilitate accuracy and completeness of datasets for all projects and investigators. Our specific aims are: (1) To integrate cutting-edge analytic approaches in the design, analysis, and interpretation of experimental studies across projects in our program; and (2) To provide secure and accessible database systems and computational infrastructure to facilitate reliable and reproducible analyses conducted by all program investigators. The Integrative Systems Biology Core leverages faculty and resources in the Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine and the Duke Molecular Physiology Institute. Dr. Thomas LaFramboise will direct the Core, with Dr. Simon Gregory as co-director. The Integrative Systems Biology Core will serve as a centralized resource for all personnel, including the leaders of the three research projects and the Bioreagents & Resource Core. The Core will assist investigators with all facets of design, computational analysis and interpretation. Established as well as novel tailored analytic methods are available to promote scientific discovery for investigators within the Core. Core personnel will interact with investigators in all stages of research, from data management, data analysis, interpretation, writing scientific manuscripts and grants, to dissemination of results. The Core will also facilitate access to secure and accessible database systems, facilitating analysis, discovery and collaboration. The Core will assist all investigators with development, management and reliability of their project data and will also integrate information across databases, such as incorporating clinical and experimental data with biospecimen data as provided by the Bioreagents & Resource Core. The Integrative Systems Biology Core will provide a natural foundation for cross-pollination among the projects and Cores, the Core personnel collaborating with all project investigators and Core directors.