Cancer Control Program: Summary/Abstract The goal of the HDFCCC Cancer Control (CC) Program is to use a multi-disciplinary team approach to understand and intervene on the structural and social determinants of cancer, leading to improved cancer health outcomes and equity. This goal will be achieved by using intra- and inter-programmatic team science to advance understanding of these multilevel determinants and to develop, translate, and implement effective behavioral, clinical, and policy interventions that will reduce the burden of cancer in the catchment area and achieve equity in cancer health outcomes. The CC Program follows a “cells-to-society” approach interrogate the biological mechanisms underlying structural and social determinants of cancer and translate these into interventions. The CC Program has the capacity to integrate discovery, intervention, and delivery research. To do so, the program (1) identifies the causes of outcomes across the cancer continuum, with attention to diverse populations, including structural, social, policy, industrial, and environmental influences on tobacco use, physical activity, other risk factors, cancer screening, and care; (2) develops, implements, and evaluates evidence-based interventions to reduce the cancer burden and improve cancer health equity in the HDFCCC catchment area; and (3) translates knowledge into effective policies and programs to achieve equity in outcomes across the cancer continuum.