Neurologic Oncology Program: Summary/Abstract The overarching scientific goal of the HDFCCC Neurologic Oncology (NE) Program is to use a team approach to advance the understanding of brain tumor biology and drive translation toward more effective and targeted treatments. This is achieved through the close collaboration of multidisciplinary clinicians and scientists devoted to studying brain tumors and combine expertise in genomics, cell signaling, developmental biology, immunotherapy, neuroimaging, epidemiology, and molecular therapeutics. A major goal of the NE Program is to more effectively move promising discoveries from the lab into clinical trials by strengthening relationships with clinical trials consortia, government agencies, and industry. All activities of the NE Program reflect the HDFCCC’s cross-cutting Themes of Impactful Discovery (Theme 1); Effective Translation (Theme 2); and Implementation and Dissemination (Theme 3) (see Director’s Overview), and are bolstered by the resources and collaborative environment provided by the HDFCCC. Specifically, NE member research focuses on (1) improving the understanding of the underlying biology of brain tumors; predicting patient disease, response, and survival in brain cancers; and (3) improving therapy for brain tumors.