# The Exercise and Physical Activity Collaborative Team (ExPACT): A MoTrPAC Clinical Center

> **NIH NIH U01** · BALL STATE UNIVERSITY · 2024 · $1,100,000

## Abstract

PROJECT SUMMARY
The Molecular Transducers of Physical Activity Consortium (MoTrPAC) is designed to discover and characterize
the range of molecular transducers that underlie the effects of exercise in humans. MoTrPAC was launched in
2016 with six adult clinical centers and a pediatric center that have collaborated to generate extensive Manual
of Operations to guide research protocols involving all aspects of the clinical operations (Phase I). Phase II
began in the fall of 2019 with all human clinical centers showing excellent progress towards initial recruitment
goals and implementation of the protocol. The initial goal set forth by NIH was to recruit 270 children (10-17
years of age) and 1980 sedentary adults (age 18 years or greater) that are randomized to endurance training
(170 youth, 840 adults), resistance training (840 adults), or non-exercise controls (50 youth, 300 adults). An
additional group of highly active endurance (50 youth, 150 adults) and resistance (150 adults) trained individuals
serve as comparators and are not participating in the MoTrPAC exercise training programs. The recruitment and
enrollment approach are sex balanced and with participants across a wide range of ages (10-17, 18-39, 40-59
and >60-year age groups) and of different races. Due to the COVID-19 pandemic, MoTrPAC activities were
suspended for over a year (beginning in March 2020) with continued constraints through 2022. Despite the
numerous challenges encountered as a result of the pandemic, recruitment activities at the adult and pediatric
clinical centers have accelerated to a rate that is projected to successfully achieve the target enrollment numbers
by the end of the new award period. This led to the NIH Common Fund to release the current NOFO (RFA-RM-
23-010) to provide MoTrPAC with funding to complete recruitment and follow-up for the clinical studies, including
finishing mechanistic randomized controlled trials of sedentary adults and children and observational studies of
highly active adults and children. This will enrich the participant cohorts that are critical to understand exercise
adaptations and heterogeneity across age, gender, and minority groups. Altogether, this extension will allow
MoTrPAC to complete the intended goals as originally envisioned and will provide a more complete public
database of the health benefits of exercise and provide insight into how physical activity mitigates disease.

## Key facts

- **NIH application ID:** 10932283
- **Project number:** 5U01AR071133-08
- **Recipient organization:** BALL STATE UNIVERSITY
- **Principal Investigator:** Thomas W Buford
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $1,100,000
- **Award type:** 5
- **Project period:** 2016-12-06 → 2026-08-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10932283

## Citation

> US National Institutes of Health, RePORTER application 10932283, The Exercise and Physical Activity Collaborative Team (ExPACT): A MoTrPAC Clinical Center (5U01AR071133-08). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10932283. Licensed CC0.

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