# Spatial single cell analysis of the human Alzheimer's Disease brain

> **NIH NIH R44** · SPATIAL GENOMICS, INC. · 2024 · $1,229,313

## Abstract

SUMMARY
The major goal of this project is to study human Alzheimer’s Disease (AD) brains using the
Spatial Genomics GenePS instrument for automated large scale gene expression analysis at
single cell resolution. At Spatial Genomics, we are commercializing the sequential fluorescence
in situ hybridization (seqFISH) technology (Eng et al, 2019) that allows thousands of genes to
be imaged directly in brain samples. We have experience working with human brains with our
seqFISH technology and will hone the technology for use in human brains. Using the seqFISH
method, we will identify changes in cell types, spatial organization of groups of cells, and
signaling interactions between neighboring cells in the human AD brain.

## Key facts

- **NIH application ID:** 10932284
- **Project number:** 5R44AG085832-02
- **Recipient organization:** SPATIAL GENOMICS, INC.
- **Principal Investigator:** Kirsten Frieda
- **Activity code:** R44 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $1,229,313
- **Award type:** 5
- **Project period:** 2023-09-21 → 2025-09-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10932284

## Citation

> US National Institutes of Health, RePORTER application 10932284, Spatial single cell analysis of the human Alzheimer's Disease brain (5R44AG085832-02). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10932284. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*