PROJECT SUMMARY The proposed project seeks to leverage our extensive network of community partners within the Black Belt region with the cancer genomic research and obesity studies proposed by RCMI scholars to provide a multilevel evidence-based study that creates a data base that combines genomic indicators with SDOH factors that will allow for more precise treatment modalities for African American and Latinx populations residing the Black Belt regions. The Community Engagement Core (CEC) advances methods for stimulating research participation, recruitment, and participant retention through collaboration between community residents and the RCMI research team. The CEC will implement the Total Cancer Care Connect (CCC) Model to support the RCMI researchers and synergize data across Cores utilizing the PhenX survey and social determinant of health indicators. The CEC will leverage resources from community organizations to form a mutually effective link between CEC team members and Black Belt Counties of Alabama. In addition, the CEC will engage undergraduate and graduate students in education dissemination, social media marketing, and community- based research methodologies that will equip them to pursue health disparities research as a form of community activism and civic responsibility.