# Core B: Clinical Informatics & Analytics

> **NIH NIH P01** · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2024 · $567,147

## Abstract

ABSTRACT: CORE B (CLINICAL INFORMATICS & ANALYTICS)
The central hypothesis of this proposed OPC-SURVIVOR P01 is to improve lifelong quality of life (QOL) and
health among oropharyngeal cancer (OPC) survivors by uncovering novel phenotypes and trajectories and
delivering non-invasive clinic-ready markers of delayed adverse treatment sequelae and novel mitigation
strategies. Three Projects are proposed, all of which require statistical support and timely collection, curation,
management, and access to data related to the MD Anderson Oropharynx (MDA-OPC) and enrichment OPC
cohorts. Core B will provide a centralized data infrastructure to facilitate data integration, and provide coordinated
analytic support for study design, data sharing, and data analysis across all Projects and Cores within the OPC-
SURVIVOR Program.
Objectives for Core B include:
• Application of a novel oropharynx cancer-specific ontology across all Projects.
• Build and optimize customized biomedical informatics pipelines for data extraction, processing, and storage.
• Data management and stewardship compliance with the data sharing policies set forth in the “Final NIH
 Policy for Data Management and Sharing.”
• Build and oversee semi-automated, robust data quality control assessment protocols.
• Build query-friendly, interactive clinical information visualization dashboards for preliminary data exploration
 by the Project and Core teams.
• Provide input on statistical design, sample size determination, analytical methods, and reporting for all
 projects and cores.
• Build risk-models to predict short-term and long-term treatment-related toxicities by incorporating medical-
 demographic variables, patient reported outcomes, blood-based, image-based, and functional biomarkers.
• For clinical trials, Core B will ensure rigorous analysis following the analysis plan laid out in the clinical trial
protocols.
• Work with Core A (Administrative Core) on Data Governance.
• Work with Core C (PROF Core) on the integrated Web-based database management system. This will
 facilitate prospective data collection, entry, quality control, integration, query, reporting, and data visualization
 of data for all studies.
• Practice methods of reproducible research and enhance study rigor.
The work of Core B is significant as standardized capture of temporal outcomes for OPC survivors and effective
knowledge representation will optimize the sustainability of the OPC-SURVIVOR Program while optimizing
health information exchange and event path planning for advanced computational modeling and characterization
of cancer treatment-related adverse effects. The advanced statistical support also provided by Core B will ensure
the successful completion of all proposed Projects.

## Key facts

- **NIH application ID:** 10933258
- **Project number:** 1P01CA285249-01A1
- **Recipient organization:** UNIVERSITY OF TX MD ANDERSON CAN CTR
- **Principal Investigator:** Amy Catherine Moreno
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $567,147
- **Award type:** 1
- **Project period:** 2024-09-01 → 2029-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10933258

## Citation

> US National Institutes of Health, RePORTER application 10933258, Core B: Clinical Informatics & Analytics (1P01CA285249-01A1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10933258. Licensed CC0.

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