PROJECT SUMMARY Vaccination has had a remarkable impact on the health of the world’s population and has been shown to be a safe, cost-effective, and powerful means of preventing deaths and improving quality of life. The University of Maryland Center for Vaccine Development and Global Health (CVD) training grant in Vaccinology has been training exceptional vaccine scientists for 25 years. Our program is firmly anchored on our past successes but has rapidly incorporated innovative new technologies, cutting-edge strategies, state of the art data analytic tools and novel educational approaches to train the next generation of leaders in Vaccinology. Collectively, the 35 faculty members participating in this training grant represent one of the largest and most accomplished teams of academic vaccine researchers in the country. These faculty study all phases of Vaccinology, each through their independent, established and well-funded research programs, and have been selected not only for their particular expertise but for their experience and commitment to training postdoctoral MDs and PhDs in vaccine research. Our highly regarded, well-established program includes a basic core curriculum designed to convey the interdisciplinary nature of the field and provide context for the specific area of research to be pursued by the trainee. Additional academic work, including required training in the responsible conduct of research, professional development, and a highly structured mentoring program, will be combined with a tailored research experience in one of two tracks: 1) Pathogenesis, Immunology and Antigen Discovery Track – preparing basic and physician scientists for a career in laboratory research, or 2) Clinical, Epidemiologic Science and Policy track -preparing physician-scientists and PhD epidemiologists in human controlled infection models, clinical trial study design and execution, and vaccine policy and epidemiology. Recruitment of trainees from underrepresented minorities is given high priority through innovative programs at the University and those specific to our training grant. Our training program is led by two Co-directors, with specific skills in the two investigative tracks and both highly qualified, and is guided by Internal and External Advisory Committees comprised of internationally recognized leaders in academic medicine and Vaccinology. The ultimate measure of our training program is to prepare our trainees to become leaders in academia, government and the private sector, and to contribute new knowledge in Vaccinology measured by excellent records of publications, funding, and awards.