PROJECT SUMMARY – CORE A The goals of the Administrative Core, (Core A), are to provide coordination and integration of all Projects and Cores and within this Program Project Grant “Integrated mechanisms of primary and chronic graft dysfunction following lung transplantation”. The goal of the Administrative Core is to disseminate resources, primary data, and scientific results between the PPG investigators and the larger scientific community. The Administrative Core will accomplish these objectives as outlined in these Specific Aims: Aim 1. To support communication between Project Investigators, Core Leaders, collaborating investigators and NHLBI Program. Aim 2. To provide a structure for the distribution of common resources as well as regulatory and budgetary oversight for Project Investigators and Core Leaders. Aim 3. To disseminate the discoveries made by PPG investigators through support of publications and presentations, and to implement sharing of materials, protocols and raw data to other institutions and investigators, including NHLBI-directed public databases/repositories. Aim 4. To foster an environment of collaborative interdisciplinary research and mentoring of students, post-doctoral fellows, and investigators. Core A will be led by Dr. Ankit Bharat, an accomplished transplant surgeon-scientist with expertise in both innate and adaptive immunity. Dr. Bharat serves as the Chief of Thoracic Surgery at Northwestern, Director of the Canning Thoracic Institute (CTI) and Director of Innovation in the Simpson Querrey Lung Institute for Translational Sciences (SQLIFTS). As the goals of SQLIFTS, the CTI and this PPG are aligned, the resources existing and being developed at Northwestern to advance clinically actionable fundamental discoveries in lung transplant immunology will provide an excellent environment and support structure for the work proposed in this application.