# Genomics, Genetics and Epigenetics Research Program

> **NIH NIH P30** · YALE UNIVERSITY · 2024 · $81,519

## Abstract

GENOMICS, GENETICS AND EPIGENETICS RESEARCH PROGRAM
PROGRAM CODE: GGE
PROJECT SUMMARY/ABSTRACT
The Genomics, Genetics and Epigenetics (GGE) Research Program consists of 61 members, including
laboratory-based scientists, clinicians/clinical trialists, and computational biologists, belonging to 17 different
academic departments, including three members of the National Academy of Sciences and three members of
the National Academy of Medicine. Program members are bound together by shared interests in studying the
cancer genome and epigenome, and in translating this knowledge into the development of new drugs, new
therapeutic strategies, and diagnostic tests. The Program has three major research aims: (1) To identify and
characterize genetic, epigenetic and transcriptional changes that drive cancer initiation, progression, and
immune evasion; (2) To develop new analytical tools, data resources, and laboratory models that enable a deep
and comprehensive understanding of the cancer genome and epigenome; and (3) To translate genomic
observations into clinically useful diagnostic and prognostic tests and develop new therapies that exploit genomic
and epigenetic alterations in cancer. GGE guides recruitment of new YCC members, fosters collaborations,
provides mentorship, and develops technology platforms and data analysis tools to accomplish the overarching
programmatic and YCC goals. In alignment with YCC priorities, the GGE Program serves the YCC catchment
area by prioritizing the study of breast and liver cancer and by focusing on cross-cutting themes including obesity,
metabolism and young adults with cancer. To achieve these goals, GGE organizes monthly research seminars
and interest groups in which members and trainees share their ongoing research to solicit feedback, nucleates
new intra- and inter-programmatic teams, and disseminates information within and across programs. GGE also
holds special retreats/symposia on cancer genetics and epigenetics topics, which provide venues to develop
collaborations and inspire the development of novel technology platforms and analytical tools that benefit all of
YCC. In 2020, GGE introduced an annual programmatic funding mechanism dedicated to the formation of new
intra-programmatic teams to kick-start promising novel GGE initiatives. These new initiatives led to GGE
research-inspired investigator-initiated clinical trials and increased collaborations between the GGE Program
and other YCC Programs. GGE has grown by 13 new members since its last renewal. GGE Program members
are training the next generation of scientists, including 240 graduate students and 232 postdocs and clinical
fellows. During this award period, GGE Program members published 520 cancer-focused papers with 34% in
high-impact journals. Of these, 42% were inter-programmatic collaborations and 16% were intra-programmatic
publications, which demonstrate strong interactions among GGE members as well as between GGE and other
programs. GGE’s total can...

## Key facts

- **NIH application ID:** 10934036
- **Project number:** 2P30CA016359-44
- **Recipient organization:** YALE UNIVERSITY
- **Principal Investigator:** LAJOS PUSZTAI
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $81,519
- **Award type:** 2
- **Project period:** 1997-07-01 → 2029-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10934036

## Citation

> US National Institutes of Health, RePORTER application 10934036, Genomics, Genetics and Epigenetics Research Program (2P30CA016359-44). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10934036. Licensed CC0.

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