# Relationships between immunosenescence, brain aging biomarkers, and cognition across nonhuman primate species of differing lifespans

> **NIH NIH R01** · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2024 · $859,240

## Abstract

Project Summary
The world’s population is aging, which brings about huge scientific challenges. Since the biological process of
aging is by far the greatest risk factor for most chronic diseases, understanding the molecular and cellular
mechanisms by which aging leads to these conditions is of vital importance to increase the health span of older
adults. Aging results in several structural and functional changes in the immune system and is clinically
associated with increases in the frequency and severity of infectious diseases and incidences of cancer,
chronic in inflammatory disorders, and autoimmunity. This general dysregulation in immune system function is
referred to as immunesenescence. Immunosenescence is a multifactorial and dynamic complex phenomenon,
which is shown as a lengthy adjusting and remodeled process existing in immune system during lifespan.
However, the mechanisms under-lying age-associated dysregulated immunity are still incompletely
understood. This proposal investigates a new perspective on immune cell markers and function with age
across NHP species with differing lifespans. In addition, we will examine the relationship between immune
aging and neurodegenerative biomarkers and cognition and compare these relationships across the NHP
species. These studies will help determine the role the immune system plays in longevity, neurodegeneration
and cognitive decline, which may allow researchers to develop and test immuno-restorative approaches with
the goal of improving longevity in humans.

## Key facts

- **NIH application ID:** 10934090
- **Project number:** 1R01AG087914-01
- **Recipient organization:** UNIVERSITY OF TX MD ANDERSON CAN CTR
- **Principal Investigator:** Michele M Mulholland
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $859,240
- **Award type:** 1
- **Project period:** 2024-09-15 → 2029-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10934090

## Citation

> US National Institutes of Health, RePORTER application 10934090, Relationships between immunosenescence, brain aging biomarkers, and cognition across nonhuman primate species of differing lifespans (1R01AG087914-01). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10934090. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*