ADMINISTRATIVE AND CLINICAL SERVICES CORE: PROJECT ABSTRACT The Director of the Administrative and Clinical Services (ACS) Core will be Dr. Susan Chang and the Associate Director will be Dr. Nancy Ann Oberheim Bush. The Administrative component will be led by Dr. Chang and the Clinical component will be led by Dr. Bush. Dr. Janine Lupo and Dr. Daniel Vigneron will serve as co-investigators in order to provide oversight of the technical aspects of the Projects planned. Dr. Chang is the co-leader of the Neuro-Oncology Program within the UCSF Helen Diller Family Comprehensive Cancer Center and is the overall PI of the P01 and was as well as the director of the Administrative Core of the current cycle. She is experienced in the coordination of multiple projects and cores and has effectively provided the leadership for the successful activities of the P01, demonstrating clear commitment to providing oversight. The specific aims of the ACS Core are to provide Administrative and Clinical services to all our Projects to accomplish their Specific Aims and Research Plans. Administrative support will include fiscal, grants management and clerical support for annual progress reports to the NCI and manuscript preparation, and organization for meetings between the key personnel from the projects and cores, as well as for meetings with the External Advisory Board. Three of the projects will involve patient research studies and the clinical component will provide the infrastructure and personnel to allow the conduct of the novel imaging studies. This will include clinical scientists, neurosurgeons, research nurses and clinical research assistants, as well as clinical space to obtain informed consent, manage, and follow patients enrolled in clinical studies within the Projects. The overall goal of the ACS Core will be to facilitate the interactions of the members of this P01, provide clinical research support for the Projects, and administratively coordinate activities of the P01 investigators. The following table depicts the distribution of effort provided to the four Projects by the two components of the ACS Core. Anticipated Distribution of ACS Core Effort Component Project 1 Project 2 Project 3 Project 4 Total Administrative 25% 25% 25% 25% 100% Clinical 20% 20% 0% 60% 100%