Project Summary/Abstract The Administrative Core is responsible for managing all project and core resources and ensuring compliance with all governmental and specific NIH regulations and requirements, including timely communication and consultation with project offices and other NCI staff. The core will convene all necessary meetings, including monthly meetings of the internal oversteering committee and annual meeting of the external scientific advisory committee. The specific aims are: Specific Aim 1. Maintain and further develop a database for epidemiological, genetic and biomarker data. The Mt. Sinai group in Toronto has harmonized data from 80 studies comprising 125,000 lung cancer patients and more than 1 million cohort individuals. The availability of this resource for Program Project leaders allows the proposed projects to be launched rapidly, efficiently and effectively. Specific Aim 2. Provide Integrative Support for Program Project Activities. A primary function of this core is to ensure the efficient functioning of Program Project relationships and communication. Communication is supported by development of clear guidelines of communication and authority, procedures for proposing new projects, regular teleconference calls, and maintenance of a website that collects and manages results from all meetings. Specific Aim 3. Develop and evaluate the translation of findings in diverse populations. A new component focusing on implementation science will be led by Washington University in St. Louis. This component leverages their implementation science core to support projects that assess the impacts of personalized evaluation and of messaging of smoking’s impact upon lung cancer risks and its mitigation, with an emphasis on minority populations. The core component also uses the Qualitative Research Core available at the Vanderbilt University Medical Center to advice in conducting focus groups targeting different communities, including minority populations that are typically underserved, in evaluating genomic risk and in the LDCT screening program.Specific Aim 4. Ensure compliance of the Program Project with all Regulatory Requirements. The administrative core supports the development of protocols that support studies. It coordinates relationships with dbGAP and other entities for whom data transfers are required. It will also manage all communications with NCI programmatic, technical and administrative staff. The administrative core also oversees financial management and ensures timely management of financial relationships among the Projects and Cores. The administrative core plays a central role in supporting investigator interactions and ensuring completion of aims. Administration for the P01 builds from successfully completed studies led by our teams of investigators across a distributed network that is managed by clear communications and extensive documentation.