ABSTRACT, Cancer Prevention and Control (CPC) Research Program The overall goals of the CPC Program, which are aligned with the Indiana University Simon Comprehensive Cancer Center (IUSCCC) Strategic Plan and guided by the unique needs and priorities of our catchment area, are to 1) decrease the incidence of cancer and 2) decrease the impact of cancer diagnoses and treatments on the lives of survivors and their families. Serving these goals, the CPC Program focuses its work on two themes, each with two aims: Theme 1) Risk Reduction and Early Detection (includes Aims 1 and 2), and Theme 2) Survivorship and Symptom Science (includes Aims 3 and 4). Within each theme, CPC members address two aims related to the identification of risk factors and the development and testing of interventions. Theme 1 is focused on risk reduction and early detection, discovering genetic, biological, social, and behavioral risk factors that contribute to the development of major cancers affecting the people of Indiana (Aim 1) and developing and evaluating innovative models and interventions that reduce cancer risk, improve screening, and increase early detection of cancers (Aim 2). Theme 2 is focused on survivorship and symptom science, identifying genetic, biological, social, and pharmacogenomic risk factors associated with cancer symptoms and treatment-related toxicities (Aim 3) and developing and testing interventions to reduce treatment-related symptoms and enhance survivorship for cancer patients and their families (Aim 4). Efforts to include underrepresented populations in research, to reduce disparities in cancer care delivery, and to improve health equity are integrated across all four aims. In 2018, the Program was evaluated as “Outstanding.” Since the prior review, CPC membership has nearly doubled from 37 (in 2018) to 63 members: 34 Full and 29 Associate Members, representing 24 Departments and seven Schools on the campuses of Indiana University at Indianapolis, Indiana University at Bloomington, and Purdue University. Since the last review, CPC funding has grown from $6.3M to $10.8M in peer-reviewed direct cost funding, representing a 71% increase. Current NCI direct cost funding is $5.1M compared to $2.8M reported in 2018, representing an 85% increase. Over the past funding period, CPC members authored 821 publications, up from 409 in 2018, representing a 100% increase. Of these, 25% are from intra-programmatic collaborations, 34% inter-programmatic collaborations, and 55% inter-institutional collaboration, with 16% in high-impact journals. The CPC Program has 27 multi-PI grants, including 6 inter-institutional, 5 intra- programmatic, 4 inter-programmatic, and 12 with other IU faculty, reflecting strong collaborations through local, national, and international networking. Leveraging our momentum, the Program will advance the IUSCCC Strategic Plan through scientific research focused on population health, health risk reduction, predictive molecular epidemiolog...