ABSTRACT, Community Outreach and Engagement (COE) The Office of Community Outreach and Engagement (OCOE) links IUSCCC researchers and the community by providing a structure that supports development of catchment-relevant research. The OCOE partners with the community to disseminate research findings that will lower the cancer burden in Indiana. We have defined the catchment area as the state of Indiana, which has a population of 6.8 million. IU Health has 16 associated hospitals throughout the state, and 88% of IUSCCC patients reside in the state. Underserved populations, who disproportionately bear the cancer burden, are the primary focus of our efforts and include the urban Black population and the rural population, which is predominantly White. Identification of priority cancers is based on the intersection of catchment area data, disparities in cancer burden, and community input. Community input, an essential component of all OCOE activities, is obtained through a statewide biennial survey, focus groups, community events, a community advisory board (CAC), a Health Equity Advisory Committee (HEAC) and inclusion of community advocates in IUSCCC research activities. After careful consideration of catchment area data and community input, the IUSCCC defined its priority cancers as lung, breast, colon, pancreatic, and HPV- related cancers. The OCOE is led by Dr. Victoria Champion (CPC), whose NCI interventions studies involve underserved populations in our catchment. The OCOE includes nine full-time staff and six patient navigators, with partial FTE support for four faculty. A COE Communications and Program Support team and a COE Data Analytics team support staff engagement with the community and provide statistical and data measurement support. Four aims frame all OCOE activities: Aim 1) assess, monitor, and prioritize the cancer burden, population characteristics, and risk factors of the catchment area; Aim 2) support the bidirectional flow of information between community partners and IUSCCC researchers; Aim 3) facilitate catchment area-relevant research, community outreach activities, and clinical trial accrual; and Aim 4) advocate for adoption of evidence- based guidelines and policy to decrease the cancer burden in Indiana. A logic model provides an organizational structure to achieve COE aims and measure impact. Community-based outreach activities are conducted in three branches: Tobacco Control, Prevention and Screening, and Survivorship and Recruitment, with a full-time staff leading each branch. An Operations Director provides administrative oversight for all branches. In addition to the CAC and HEAC, a Research Advisory Committee (RAC) composed of researchers from all four Research Programs support researchers engagement in the community. Our partnership with the community has impacted the smoking rate in Indiana, which decreased from 21.1% in 2019 to 17.3% in 2022. In addition, up-to-date HPV vaccinations rose from 29.4% in 2019 to 55.2...