ABSTRACT, Leadership, Planning, and Evaluation The Indiana University Simon Comprehensive Cancer Center (IUSCCC) has established an effective process for Leadership, Planning, and Evaluation that receives input from its senior leaders, Research Program leaders, and members as well as internal and external advisory committees. The current grant period has seen recruitment of a new Director (Dr. Kelvin Lee) and expansion of the senior leadership team to oversee new IUSCCC-wide initiatives through creation of Associate Director positions in Data Science (Dr. Kun Huang), Diversity, Equity, and Inclusion (Dr. Antwione Haywood), and System Integration (Ms. Katie McGill, IU Health). These changes have enhanced formal strategic integration and coordination among IUSCCC, the IU School of Medicine (IUSM), and the IU Health system. Based on internal and external input, the IUSCCC leadership has developed and implemented its Strategic Plan and has continuously assessed the plan's impact on the four Research Programs and multiple Shared Resources in advancing the IUSCCC mission to serve the population of Indiana and beyond. The Strategic Plan has evolved from 2018 through its most recent update in 2023 to a framework that contains three major components: Foundational Organizational Capabilities; Integrating Efforts (education, data science, community outreach and engagement); and Cross-Cutting Scientific Themes (mechanism-based medicine, bench↔bedside↔main street translational research, population health, social responsibility and policy). Following this Strategic Plan, the senior leadership has implemented a number of actions over the current grant period. These include appointment of new leadership in the four Research Programs: Cancer Prevention and Control (Dr. Katzenellenbogen), Experimental and Developmental Therapeutics (Drs. Opyrchal and Pollok), Tumor Microenvironment and Metastasis (Dr. Fishel), and Hematopoiesis and Hematologic Malignancies (Dr. Salman). Additionally, new transdisciplinary research initiatives (e.g., the Brown Center for Immunotherapy), translational development platforms (e.g., the Cancer Drug Discovery and Development Accelerator), and educational programs (e.g., the Translational Cancer Biology PhD program) have been launched. There has also been significant expansion of the Office of Community Outreach and Engagement and development of the Plan to Enhance Diversity (PED). These and other initiatives drive IUSCCC's mission to impact research, patient care, and education both locally and globally. To accomplish these, the Leadership, Planning, and Evaluation aims are to: 1) further increase the depth of Team Science, both intra- and extramurally, geared towards reducing the burden of cancer, 2) amplify cancer outreach and community engagement activities within our catchment area and beyond, 3) create a strong planning process that aligns the tripartite mission of IUSCCC, IUSM, and the clinical enterprise through strategic plannin...