PROJECT SUMMARY/ABSTRACT This application is a renewal of our longstanding training grant in Pediatric Allergy and Immunology. This training program is designed to provide physicians and qualified Ph.D. candidates with the skill set necessary to become successful physician scientists in the field of Allergy and Immunology. It is fully expected that all trainees will go on to pursue full-time careers in academic medicine and the training is specifically designed to accomplish that goal. Each trainee spends the vast majority of his/her time in direct laboratory, clinical, and/or translational research, supplemented with formal course work and seminars, while fulfilling required clinical training responsibilities. The Program Director, Dr. Robert Wood, actively oversees the training program for each trainee and a single faculty member acts as the primary preceptor for each trainee. In addition, each trainee's program is guided by a Scholarly Oversight Committee, charged with overall guidance regarding his/her research, helping to select those courses and / or degrees which will be most important to the trainee's development, and ensuring that the trainee's other activities are appropriately limited so that success in research training – the primary mission of the training program – is ensured. As will be detailed through this application, the program has enjoyed great success in accomplishing its mission and is currently exceedingly well positioned to continue at that same high level of achievement. The 24 faculty included in this training grant include of 16 professors, 4 associate professors, and 4 assistant professors. These faculty bring a wide range of expertise as well as a wealth of funding. In addition to the five core faculty with primary appointments in our division, we have forged close relationships with other faculty from across the Johns Hopkins community, 19 of whom are included in this application. These include members of the divisions of Pulmonary Medicine in the Department of Pediatrics, the divisions of Clinical Immunology, Pharmacology, and Pulmonary Medicine in the Department of Medicine, the divisions of Environmental Health Sciences, Biostatistics, Child Health and Development, Health Policy, and Epidemiology in the Johns Hopkins Bloomberg School of Public Health, and the Institute of Genetic Medicine. Each of these faculty members is an active collaborator with one or more members of our division and each has actively participated in the training of our fellows and junior faculty, demonstrating an enormous commitment to our training program and, most importantly, providing a wide and dynamic range of research opportunities. We are seeking funding for 3 trainees per year, with the intent being to enroll one new trainee per year where M.D. candidates are accepted into a three-year, research intensive fellowship. However, we will also leverage each funded position to maximize research time, so that some trainees will be funded ...