# PRomoting Excellence through Pain and Addiction Research Enhancement (PREPARE)

> **NIH NIH T90** · WASHINGTON UNIVERSITY · 2024 · $172,596

## Abstract

ABSTRACT
Pain and substance use disorders (SUD) represent arguably the two most prevalent and costly public health
condition in the United States. While vitally important to consider, the intersection of pain and SUD is not just
limited to opioid use/abuse. Patients being treated for SUD (opioid and non-opioid) commonly report chronic
pain, and, in turn, a history of SUD occurs frequently among patients who receive treatment for chronic pain.
Despite the enormous need for new safe and efficacious treatments, the intersection of pain and SUD research
remains a surprisingly underexplored area of inquiry, which has resulted in excessive knowledge gaps and
limited pain treatment options for people with or in recovery from a SUD. To address this unmet need, we have
developed a new postdoctoral training program: the Promoting Excellence through Pain and Addiction Research
Enhancement (PREPARE) T90/R90 Training Program. A defining feature of the PREPARE Program will be an
emphasis on social determinants of health (SDOH) as they relate to chronic pain and SUD clinical research.
SDOH define the conditions in which people are born, grow, live, work, and age, and the inequities in power,
money, and resources that are often responsible for disparities in pain and SUD outcomes across the U.S. Our
overall goal is to develop outstanding independent investigators capable of sustaining productive clinical and
translational research careers addressing the biopsychosocial (emphasis on social) mechanisms underlying
chronic pain and SUD development, and/or designing clinical interventions to relieve pain and ameliorate SUD.
To facilitate progress toward this goal, the PREPARE Program will complete the following. 1. Recruit and train
promising early career investigators (postdoctoral fellows) to conduct mechanistically-based clinical research in
pain and SUD. 2. Implement an integrated training program that will equip trainees with new research skills and
the knowledge to apply these skills to important and unanswered questions regarding pain and SUD. 3. Create
a culture of responsible research conduct and professional excellence to ensure trainees aspire to high
standards of scientific integrity and quality. PREPARE will leverage an excellent infrastructure and collaborative
network at the Washington University School of Medicine in St. Louis. We anticipate significant success in
recruiting and training an outstanding and diverse group of trainees during the initial funding cycle. Members of
the training faculty boast excellent track records of research funding and mentoring experience. Prepare requests
support for five postdoctoral trainees (4 T90, 1 R90) from a variety of clinical training backgrounds, each of whom
will work with their multidisciplinary mentoring team to create and implement a tailored independent development
plan as the blueprint for their training. Trainees will achieve their research and career development objectives
through a combination of did...

## Key facts

- **NIH application ID:** 10935002
- **Project number:** 1T90NR021683-01
- **Recipient organization:** WASHINGTON UNIVERSITY
- **Principal Investigator:** Burel R. Goodin
- **Activity code:** T90 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $172,596
- **Award type:** 1
- **Project period:** 2024-08-12 → 2029-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10935002

## Citation

> US National Institutes of Health, RePORTER application 10935002, PRomoting Excellence through Pain and Addiction Research Enhancement (PREPARE) (1T90NR021683-01). Retrieved via AI Analytics 2026-06-12 from https://api.ai-analytics.org/grant/nih/10935002. Licensed CC0.

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