ADMINISTRATIVE CORE SUMMARY/ABSTRACT The Administrative Core of the proposed NIA PO1 Center at the University of Pennsylvania (Penn) Perelman School of Medicine (PSOM) is key to accomplishing the goals of all Project and other Cores. The proposed PO1 Center focuses on priorities that address Alzheimer’s Disease and related dementias (ADRD) in the topic areas of Lewy body disorders (LBD), and multiple etiology dementias, with projects that all address the central question of why some LBD patients develop cognitive decline early, while others develop these symptoms much later, or not at all. We focus on mechanisms, with the goal of deriving insights that may lead to much-needed therapies for these pathological processes. We center our program in human-derived materials, leveraging the longstanding collection of human brain tissue and biofluids from individuals with neurodegenerative disorders at our center. The seven Specific Aims for the Administrative Core fall into three clusters. Aims 1, 2, and 3 broadly support the Research Projects by (1) overseeing fiscal and budgetary matters, (2) enhancing synergy within the PO1 Center by organizing internal meetings, including “inverted meetings,” and (3) conducting reviews of the PO1 Center by an External Advisory Committee, which will include one individual affected by LBD (as patient, caregiver, or other lay advocate). Aims 4, 5, and 6 increase the impact of the Center’s activities by (4) fostering dissemination of research findings from the Projects and Cores, (5) staying up to date on NIH policies concerning human subjects, data sharing, resource sharing, and informing all investigators within the Center to ensure compliance, and (6) sharing human biosamples, human biosample-derived strains, and PO1 center data with outside investigators, in collaboration with the Resource Core and the Data Management and Statistics Core. Aim 7 leverages the interdisciplinary nature of the PO1 center to develop translational researchers.