# Core C: Resource Core

> **NIH NIH P01** · UNIVERSITY OF PENNSYLVANIA · 2024 · $445,427

## Abstract

Resource Core: Abstract
Nearly all neurodegenerative disorders are characterized by progressive accumulations of pathological
deposits of disease protein aggregates within cells, blood vessels or in the neuropil. These deposits are the
signature CNS lesions that define these disorders as exemplified by specific alpha-synuclein aggregates which
are required for the postmortem diagnosis of Lewy body disease. However, Alzheimer’s disease
neuropathologic change consisting of amyloid plaques and neurofibrillary tangles in addition to TDP-43
proteinopathy also contribute to cognitive dysfunction in the setting of Lewy body disease. A major focus of
this Resource Core is to provide resources to investigators and collaborators in support of scientific studies to
better understand the mechanisms that cause dementia in Lewy body disorders. A comprehensive post-
mortem brain examination of individuals followed longitudinally in the Clinical Core provides definitive
classification of the underlying neuropathology using standardized criteria in addition to the exhaustive
documentation of co-morbid neurodegenerative disease pathologies in each case irrespective of clinical
phenotype. Fixed and frozen tissues, DNA, biofluids and alpha-synuclein proteopathic seeds are banked and
distributed to investigators in all four projects to further both clinicopathologic and basic research studies.
Thus, this Resource Core is a vital component of this Program Project Grant by grounding mechanistic
research projects to the human disease by use of human and recombinant resources in support of the overall
goal of better understaning how genetic, biochemical and pathologic alpha-synuclein diversity drives cognitive
dysfunction and dementia.

## Key facts

- **NIH application ID:** 10935307
- **Project number:** 1P01AG084497-01A1
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **Principal Investigator:** Edward Byung-Ha Lee
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $445,427
- **Award type:** 1
- **Project period:** 2024-09-15 → 2029-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10935307

## Citation

> US National Institutes of Health, RePORTER application 10935307, Core C: Resource Core (1P01AG084497-01A1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10935307. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*