Data Management and Statistics Core Core Leader: Sharon X. Xie; Co-Investigator: Corey McMillan Summary/Abstract: Data Management and Statistics Core The Data Management and Statistics (DMS) Core is an integral part of this P01 Program Project Grant (P01) “Mechanisms Underlying Heterogeneity of Cognitive Outcome in Synucleinopathy” at the University of Pennsylvania (Penn) Perelman School of Medicine (PSOM). The goal of the DMS Core is to support the data management, database, statistics, bioinformatics, and related computational needs of Penn P01 investigators, as well as provide data sharing support to investigators outside the P01 and Penn. The services provided by the DMS Core include: (a) support for data form/questionnaire design and development, database development and management, data entry, database audit trail, database security, database backup, and stringent data quality control procedures, (b) computing and programming support for all Penn P01 activities, including implementation and integration of hardware and software upgrades necessary for data management and research, routine and archival off-site backup of computing systems central to the P01, (c) biostatistical support for all study aspects of Projects and Cores from inception to publication, including development of study design, performing sample size and power calculations, and performing analyses of the P01 data, (d) integration of bioinformatics and biostatistics expertise to support analysis of genomics and proteomics data, (e) development of new statistical methodologies and extension of existing methodologies where needed for analyses of the P01 data, (f) Implementation of data sharing between the P01 and other researchers outside the P01 and Penn in partnership with the National Institute on Aging. Thus, the DMS Core plays an important and significant role that is critical to the progress of research and the conduct of studies in the Penn P01, and it will foster collaborative interactions between the Penn P01 and researchers outside the P01.