Core B Abstract The mission of the Biostatistics & Bioinformatics Core (Core B) is to support the SPORE, Career Enhancement Program, and the Development Research Program projects through a variety of services, support, methods development and computational infrastructure. Core B is led by faculty geneticists, statisticians, biostatisticians and is staffed by senior LCCC Bioinformatics and Biostatistics shared resource members who will directly participate in all projects and be integral partners with each project. This centralized core will provide scientific leadership and resources for statistical and bioinformatics analysis of complex data sets, and utilizes existing shared resources supported by the Lineberger Comprehensive Cancer Center including strong support for informatics, high performance computing clusters, and biostatistics support. This Core and its personnel have a track record of translational and computational accomplishments that will be applied to new cutting-edge technologies including single cell sequencing and spatial genomics approaches. Complementary skills possessed by the Core faculty will also lead to the application and development of (as needed) cutting- edge approaches for to cross-platform data integration and high-dimensional biomarker discovery to facilitate patient subtyping and optimize clinical decision-making. The Biostatistics & Bioinformatics Core (Core B) will provide support for each of the SPORE projects as well as the Career Enhancement Program (CEP) and the Development Research Program (DRP).