# Core D: Long-Term Follow-Up

> **NIH NIH P01** · FRED HUTCHINSON CANCER CENTER · 2024 · $418,106

## Abstract

PROJECT SUMMARY/ABSTRACT
This Core supports Projects 2 and 3 by collecting long-term follow-up data for patients who have undergone
hematopoietic cell transplantation (HCT) or cellular immunotherapy (IMTX) at the Fred Hutchinson Cancer
Center (FHCC), University of Washington (UW) or Seattle Children’s Hospital (SCH) under protocols developed
at the FHCC. The services of this core unit address several closely related areas: identification and management
of late complications, data and research sample collection, database assembly and evaluation of the efficiency,
accuracy, quality and utility of the data collection and the system in which the data are stored. We have
developed several mechanisms to support this overall goal.
 1. We will collect long-term data focused on survival, therapy-related complications, and health relevant to
 the clinical research studies supported by this grant. This includes the prospective cohort of patients to
 be studied in Projects 2 and 3 of this grant application who require follow-up for at least 15 years after
 treatment. For this purpose, a system has been established to track and maintain contact with patients
 and referring physicians so that data can be collected at specified time points after treatment.
 2. We will assist investigators in obtaining information and research biospecimens that are not routinely
 collected but are needed for individual research projects.
 3. We will continue to identify barriers that interfere with long-term follow-up of geographically dispersed
 patients and develop methods to overcome these barriers.
 4. We will continue to evaluate the research methods employed in data collection and database
 management, including the efficiency, reliability, validity and utility of the instruments used for data
collection.
The data generated from this core unit will assist project leaders in understanding the long-term efficacy of
experimental treatments and identifying late complications and mechanisms of relapse after cellular therapy with
HCT or targeted T cell therapies. Close coordination with the clinical Long-Term Follow-Up Program (LTFU) that
provides telemedicine services ensures prompt notification of clinical events such as relapse. Integrating long-
term data collection efforts across the Projects through Core D provides efficient services to support this
Research Program.

## Key facts

- **NIH application ID:** 10935590
- **Project number:** 2P01CA018029-48A1
- **Recipient organization:** FRED HUTCHINSON CANCER CENTER
- **Principal Investigator:** STEPHANIE J LEE
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $418,106
- **Award type:** 2
- **Project period:** 1997-08-28 → 2029-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10935590

## Citation

> US National Institutes of Health, RePORTER application 10935590, Core D: Long-Term Follow-Up (2P01CA018029-48A1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10935590. Licensed CC0.

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