# Multiscale Systems to Elucidate Susceptibility and Cardioprotective Mechanisms in Cardio-oncology

> **NIH NIH P01** · STANFORD UNIVERSITY · 2024 · $2,415,648

## Abstract

PROJECT SUMMARY (OVERALL)
The overarching goal of this Program Project Grant (PPG) is to elucidate mechanisms of cardiotoxicity
and to develop a platform to test cardiotoxicity of new cancer therapeutics. Project 1 (Moslehi) will use
a combination of mouse- and cell-based models to address the central question of whether
cardiotoxicity associated with ibrutinib is on- or off-target. Project 2 (Wu) will establish novel pooled
“cell villages” from patients to map genetic inter-individual difference in response to kinase inhibitors to
elucidate genetic susceptibility to cardiotoxicity from kinase inhibitors. Project 3 (Mercola) aims to
identify mechanisms that protect against cardiotoxicity of ibrutinib using a pipeline for discovery of
protective targets based on reverting epigenomic consequences of exposure to a toxic drug. All three
projects will be supported by an iPSC Processing Core (Core B) (Sallam) that will facilitate a unique
repository of iPSC lines from patients with ibrutinib treatment. An Administrative Core (Wu) will
support all three projects and the core to facilitate a fully integrated program project and enable high-
impact research. The proposed PPG and assembled group collectively introduces synergies that will
significantly impact the field of cardio-oncology and make translationally actionable inroads to decrease
the burden of adverse effects of cancer therapeutics.

## Key facts

- **NIH application ID:** 10935736
- **Project number:** 2P01HL141084-06
- **Recipient organization:** STANFORD UNIVERSITY
- **Principal Investigator:** Joseph C. Wu
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $2,415,648
- **Award type:** 2
- **Project period:** 2019-09-01 → 2029-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10935736

## Citation

> US National Institutes of Health, RePORTER application 10935736, Multiscale Systems to Elucidate Susceptibility and Cardioprotective Mechanisms in Cardio-oncology (2P01HL141084-06). Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/grant/nih/10935736. Licensed CC0.

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