CORE A: SUMMARY/ABSTRACT This Program Project comprises four individual projects, which will: extend the WISDOM Study to evaluate the use of subtype-specific risk models and associated screening recommendations in improving key metrics of screening outcomes (Project 1); continuously develop better subtype-specific risk models using large population cohorts and cases where we have imaging and genomic information that can be validated using the WISDOM Study and other cohorts (Projects 2 and 3); and use the MISCAN model to estimate the long-term benefits, harms, and cost-effectiveness of the subtype-specific risk approach and set thresholds/milestone goals for subsequent updates to the WISDOM platform (Project 4). The primary aims of the Administration, Communication and Project Management Core are to ensure program integration, collaboration and scientific advancement by providing project management leadership and administrative support to the Projects and Cores in four areas: Communications and meeting coordination, Project management and oversight, Partnerships and external relations, and Program integration support. Aim 1: Administrative Support to facilitate communication amongst investigators, projects, participants, public, private partners, NCI, DSMB, Scientific Advisory Board Aim 2: Provide project management for all of the projects within this P01 - support and tracking of the individual projects and cores to ensure that all projects are completed on time and on budget Aim 3: Facilitate transition of successful products and models developed within the Program Project and support WISDOM protocol development as part of the WISDOM Stakeholder process. The Administration, Communication and Project Management Core is the organizational hub of the Program Project. A strong organizational hub focused on program progress, information exchange and readily available data and resources is of utmost importance for the success of the Program. This includes the Cores and Projects targeting risk assessment, imaging, iterative testing of risk models and screening thresholds, data collection and educational tools, as well as managing advisory boards and importantly, stakeholder development and ongoing engagement. A critical role of Core A is to facilitate collaboration and communication across projects and teams, a role which Core A’s leadership has demonstrated within Athena, WISDOM, I-SPY 2, and MCL consortium with great success. This is an experienced, multidisciplinary team capable of leading and managing large, complex clinical trials with integrated biomarker components that has a proven track record for rapidly and successfully integrating new processes and procedures using tested, systems-based approaches for management and project execution.