# Beyond insulin: Next-generation modulators of insulin receptor for glycemic control

> **NIH NIH DP1** · STANFORD UNIVERSITY · 2024 · $772,383

## Abstract

This research project is dedicated to the development and optimization of non-peptide ligands
designed to activate insulin receptors, fundamentally transforming approaches to glycemic control
in the management of diabetes. The innovative strategy at the core of this project involves
designing distinct ligands for insulin receptor binding sites. This approach aims to uncover a new
generation of receptor modulators that might be suitable for oral administration, addressing a
long-standing challenge in diabetes therapeutics. By dissecting and specifically targeting the
insulin receptor binding sites with designed ligands, the project has the potential to yield
unprecedented insights and introduce transformative therapeutic options. If successful, the
outcomes of this research will not only provide a novel and more convenient treatment alternative
for diabetes but will also significantly improve the quality of life and health outcomes for millions
of individuals living with this chronic condition.

## Key facts

- **NIH application ID:** 10937825
- **Project number:** 1DP1DK140025-01
- **Recipient organization:** STANFORD UNIVERSITY
- **Principal Investigator:** Danny Hung-Chieh Chou
- **Activity code:** DP1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $772,383
- **Award type:** 1
- **Project period:** 2024-09-01 → 2027-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10937825

## Citation

> US National Institutes of Health, RePORTER application 10937825, Beyond insulin: Next-generation modulators of insulin receptor for glycemic control (1DP1DK140025-01). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10937825. Licensed CC0.

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