# Molecular basis of antibiotic resilience in Mycobacterium tuberculosis

> **NIH NIH R01** · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · 2024 · $848,869

## Abstract

Summary
We have identified a novel driver of treatment failure in Mycobacterium tuberculosis, termed antibiotic
resilience, where the bacteria have improved recovery after antibiotic exposure. Population genomic and
genetic studies implicate a novel transcriptional regulatory network in control of antibiotic resilience, which we
will dissect through genomically informed structure-function studies and in treatment models.

## Key facts

- **NIH application ID:** 10938757
- **Project number:** 1R01AI184469-01
- **Recipient organization:** HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH
- **Principal Investigator:** SARAH FORTUNE
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $848,869
- **Award type:** 1
- **Project period:** 2024-06-01 → 2029-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10938757

## Citation

> US National Institutes of Health, RePORTER application 10938757, Molecular basis of antibiotic resilience in Mycobacterium tuberculosis (1R01AI184469-01). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10938757. Licensed CC0.

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