# P30 - Core Grant for Vision Research

> **NIH NIH P30** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $653,524

## Abstract

OVERALL
PROJECT SUMMARY/ABSTRACT
The broad objective of this NEI Center Core Grant for Vision Research application is to facilitate
study of the structure, development and function of the visual system in health and in blinding
diseases, with the aim of preventing, mitigating or curing such diseases, or the restoration of lost
vision, through the application of the most sophisticated available techniques. Four resource and
service Cores will help achieve the broad objective, as follows:
I. Image Analysis and Graphics Core: Morphometric analysis; computer-aided image analysis;
 production of graphics for data analysis, presentation and publication
II. Morphology Core: Histology (paraffin and plastic embedding, sectioning and staining, frozen
sectioning for immunohistochemistry), ocular imaging (slit lamp examination and photography,
Micron III fundus photography (with fluorescein angiography) and optical coherence tomography
(OCT), biometric Bioptigen OCT) and visual functional testing (ERG, OptoMotry and IOP) and
in vivo rodent eye injection with electroporator set up. Microscopy (light microscopy - brightfield,
darkfield, phase contrast, DIC and fluorescence) and photomicrography, and advanced
microscopy using a combination of spinning disk and confocal microscopes).
III. Computer/IT Core: Programming for custom data acquisition and storage pipelines and data
analysis algorithms utilizing High Performance Computing (HPC) hardware. Provide support for
electrophysiology, RNAseq, multi-photon fluorescence microscopy and other modalities as
needed.
IV. Rapid-Prototyping and Design Core: Design of new unique research equipment plus
education and training of users, empowering them to participate in the manufacturing,
construction, maintenance, and upgrading of their unique research equipment designs.
This is an application of a NEI Center Core Grant for Vision Research competing renewal
submitted by the Principal Investigator and 14 other vision scientists who currently hold 17 active
NEI R01 research grants. In addition, the UCSF vision research community supported by the NEI
Vision Core Grant comprises 20 NEI- supported scientists with grant mechanisms other than
active R01, 5 with other NIH funding, and 7 with private funding. There are 41 Vision scientists
with active research programs, overall, each using at least one Core at a moderate or extensive
level. Using traditional and innovative approaches, this Core Vision Research Grant has been
highly successful and instrumental in enhancing the productivity and impact of vision research,
supporting young investigators to obtain data to apply for their first NEI grants, attracting scientists
to vision science and facilitating collaborative studies on the visual system at UCSF.

## Key facts

- **NIH application ID:** 10939260
- **Project number:** 2P30EY002162-46
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Erik M Ullian
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $653,524
- **Award type:** 2
- **Project period:** 1997-03-01 → 2025-09-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10939260

## Citation

> US National Institutes of Health, RePORTER application 10939260, P30 - Core Grant for Vision Research (2P30EY002162-46). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10939260. Licensed CC0.

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