# Cross platform analysis of drug targets and toxicity of bath salts

> **NIH NIH U01** · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · 2024 · $389,265

## Abstract

PROJECT SUMMARY/ABSTRACT
The parent award is focused on studying the mechanisms of novel psychoactive agents, with an emphasis on
phenethylamines. Some of these agents are hallucinogenic and induce pronounced long term changes in
dendritic branching and synaptic plasticity (termed as psychoplastogens). Even acute treatments with
dimethyltryptamine (DMT), an agent from a related class (an indole-alkylamine) results in long term synaptic
rewiring. The mechanisms behind these effects are the focus of significant interest for neuropsychiatric disorders
and may have applications for dementia and Alzheimer’s disease (AD). Recent evidence indicates they may
work via direct activation of TrkB, but most investigations have focused on traditional targets associated with
these agents, such as 5-HT1A/2A, and few studies have used AD models. We propose to study binding partners
of psychoplastogens and effects of kinase signaling and gene expression in human AD patients derived iPSCs
via multi-omic analysis.

## Key facts

- **NIH application ID:** 10939799
- **Project number:** 3U01DA054330-03S1
- **Recipient organization:** UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS
- **Principal Investigator:** Isaac T Schiefer
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $389,265
- **Award type:** 3
- **Project period:** 2022-09-15 → 2027-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10939799

## Citation

> US National Institutes of Health, RePORTER application 10939799, Cross platform analysis of drug targets and toxicity of bath salts (3U01DA054330-03S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10939799. Licensed CC0.

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