# Clinical Core

> **NIH NIH U19** · UNIVERSITY OF PENNSYLVANIA · 2024 · $2,538,101

## Abstract

CLINICAL CORE
ABSTRACT
This Clinical Core will implement first in human PET imaging with new radiotracers targeting α-synuclein (α-syn)
and 4 repeat tau (4R tau). These two types of radiotracers are key for investigation of Parkinson disease (PD)
and Multiple Systems Atrophy (MSA), diseases that have α-syn brain pathology, and Progressive Supranuclear
Palsy (PSP) and frontotemporal dementias (FTD) that have 4R tau brain pathology. A critical part of these studies
is the Clinical Core driven consensus diagnosis conferences to implement careful evaluation of each participant
since MSA and PSP can be particularly difficult to diagnose clinically. This represents a critical step for
understanding the clinical manifestations of these disorders and for developing new treatments for these and
related neurodegenerative diseases.

## Key facts

- **NIH application ID:** 10940633
- **Project number:** 2U19NS110456-06
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **Principal Investigator:** JOEL Synes PERLMUTTER
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $2,538,101
- **Award type:** 2
- **Project period:** 2019-09-24 → 2029-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10940633

## Citation

> US National Institutes of Health, RePORTER application 10940633, Clinical Core (2U19NS110456-06). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10940633. Licensed CC0.

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