# CHEMICAL SCREENING AND OPTIMIZATION FACILITY - SCALABLE QUANTITIES

> **NIH NIH N01** · SRI INTERNATIONAL · 2023 · $773,237

## Abstract

The Chemical Screening and Optimization Facility (CSOF) fulfills a unique role by identifying, optimizing and conducting production identified small molecules for contraceptive and reproductive health related (e.g., infertility, polycystic ovarian syndrome, fibroids, endometriosis, dysmenorrhea, adenomyosis, gynecologic and/or pelvic pain, and vulvodynia, premature birth, placenta health, improving lactation quality and quantity, preeclampsia, perinatal microbiome, gestational diabetes, inflammation, bacterial infections, viral infections, necrotizing enterocolitis, bronchopulmonary dyplasia, pre-term birth, fetal growth restriction, mastitis, Cushing's disease, Down Syndrome, Ricketts, Muscular Dystrophy, Rett syndrome, sepsis, or Autism) research. One approach is to conduct scalable quantity projects of identified small molecule(s) (e.g., natural product) and/or large molecule (e.g., polymer) that afford a contraceptive effect against a validated target or as a treatment for an identified reproductive health related indication. The research contained within this task order will encompass generation and purification of small or large molecules where purity of the final product shall be verified using methods including, but not limited to, Proton-Nuclear Magnetic Resonance (1H-NMR),  Carbon-13-Nuclear Magnetic Resonance (C-NMR), Liquid Chromatography–Mass Spectrometry (LC-MS), High-Performance Liquid Chromatography (HPLC), Infrared (IR) Spectroscopy, melting point.

## Key facts

- **NIH application ID:** 10942882
- **Project number:** 75N94023D00006-0-759402300002-1
- **Recipient organization:** SRI INTERNATIONAL
- **Principal Investigator:** LEYI GONG
- **Activity code:** N01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $773,237
- **Award type:** —
- **Project period:** 2023-09-29 → 2026-09-27

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10942882

## Citation

> US National Institutes of Health, RePORTER application 10942882, CHEMICAL SCREENING AND OPTIMIZATION FACILITY - SCALABLE QUANTITIES (75N94023D00006-0-759402300002-1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10942882. Licensed CC0.

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