# Addressing unmet needs: intervention approaches for mental health among people with tuberculosiss in Uganda

> **NIH NIH K01** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $134,811

## Abstract

PROJECT SUMMARY
Tuberculosis (TB) and common mental disorders (CMDs) are both leading causes of death and disability
worldwide and are intertwined health states that often co-occur but are rarely addressed together. People with
TB and diagnosis of at least one CMD have double the risk of loss to follow-up, treatment failure, or death
along with increased odds of non-adherence to TB treatment. Thus, there is an urgent need to identify and
assess evidence-based interventions to address CMDs as part of routine TB care to improve wellbeing and TB
treatment outcomes among people with TB.
The overall objective of this application is to identify and adapt an intervention to address CMDs among people
being treated for TB. The central hypothesis is that an existing mental health intervention for CMDs is
appropriate for and can be adapted and integrated into routine TB care. The central hypothesis will be tested
by pursing three specific aims: 1) examine the relationship between CMDs and associated factors with TB
treatment adherence and treatment outcomes during the TB treatment period to identify the most critical timing
and type of intervention needed, 2) adapt and explore barriers and facilitators for implementation of an
evidence based CMD intervention for integration into routine TB treatment services, and 3) pilot an intervention
aimed at improving TB treatment outcomes among individuals with CMD symptoms. The results of this work
will provide critical preliminary data for an NIH R01 application evaluating effectiveness of the adapted
intervention among people with TB on treatment.
Dr. West’s career goal is to become an independent investigator focused on improving TB treatment outcomes
in high-burden settings by addressing the mental health needs of people with TB. To support her path to
independence, the proposed work will be paired with a dedicated, multidisciplinary mentorship team and
training in longitudinal study design and conduct (Aim 1), implementation sciences (Aims 2 and 3), and
interventional research (Aim 3). UCSF is an outstanding environment that is committed to junior investigators
with extensive resources for research and career development. Thus, the K01 award will provide Dr. West with
the critical mentorship, training, resources and experience to become an international leader in mental health
research among people with TB.

## Key facts

- **NIH application ID:** 10950081
- **Project number:** 1K01AI185258-01
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Nora Solon West
- **Activity code:** K01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $134,811
- **Award type:** 1
- **Project period:** 2024-09-01 → 2029-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10950081

## Citation

> US National Institutes of Health, RePORTER application 10950081, Addressing unmet needs: intervention approaches for mental health among people with tuberculosiss in Uganda (1K01AI185258-01). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10950081. Licensed CC0.

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