ADMINISTRATIVE CORE: SUMMARY This Administrative Core provides support and oversight for the P20 FORWARD Center. The Core will have two major tasks: 1) to facilitate the administration and higher-level management of the Center, providing access to expertise and resources as needed by the ESIs to achieve their immediate research goals, and 2) to support the career development of the ESIs through the successful completion of the project and the development of emergent new research proposals. The Core will also facilitate interactions with the NIDDK CAIRIBU and the broader research community as well as compliance with appropriate local and federal regulations and data availability requirements. The Core Director provides advice, encouragement, and resources, but the overall research project was developed, and will be executed, primarily by the three co-investigator ESIs. The Core will provide a central communications hub between the ESIs who are working in three different locations, providing easy access to videoconferencing for both group discussions and communication with outside experts and with the broader benign urology research community. All three ESI, as well as the PI, have previously been, and continue to be, involved with CAIRIBU and are familiar with the organization and its various in-person and online meetings. The Core Director will ensure that the ESIs attend scheduled CAIRIBU meetings, will arrange for scientific updates by Center investigators at the CAIRIBU Annual Meeting, and facilitate ongoing communication with the CAIRIBU Interactions Core providing an interface with NIDDK. The Research Project will provide a molecular and cellular description of mouse models of prostate inflammation and hyperplasia, their individual transcriptomic, histologic, and functional characteristics, and the parallels to, and differences from, specific aspects of human BPH. The project addresses a major knowledge gap and will generate data that will support the development of new funding proposals to support funding proposals. The Core Director will provide access to resources including human patient transcriptomic databases and annotated human clinical samples that will be used to compare mouse models to human BPH. The Administrative Core will ensure that studies are completed and submitted for publication in a timely manner. The Core will be responsible for ensuring that data are deposited in a publicly available and easily understood form in a timely manner and will publicize the development of a database that can be interrogated through an RShiny application to be developed in the project. The major long-term goal of this Center is to help the ESIs to move to independent research careers. The project will develop data that can be used to support funding proposals. Such proposals require rigorous development to allow them to succeed in the review process. As such, the Administrative Core will oversee the establishment and regular meetings of commi...