# PA1627: a new regulator of the Type III secretion system

> **NIH NIH R03** · EAST TENNESSEE STATE UNIVERSITY · 2024 · $66,320

## Abstract

Project Summary
New targets to combat Pseudomonas aeruginosa is paramount given the difficulty of treating
Pseudomonas infections and increasing drug resistance of this pathogen. A major goal has been
to target the type III secretion system that directly delivers toxins into host cells. However, this
has yet to result in a clinical therapeutic. We recently discovered an unannotated regulator,
PA1627, that controls expression of the type III secretion system. In this proposal, we will
determine the regulation of PA1627 and determine how PA1627 controls the type III secretion
system. Understanding this new level of control of the type III secretion can lead to new
possibilities for combatting P. aeruginosa.

## Key facts

- **NIH application ID:** 10952452
- **Project number:** 1R03AI185654-01
- **Recipient organization:** EAST TENNESSEE STATE UNIVERSITY
- **Principal Investigator:** Christopher L. Pritchett
- **Activity code:** R03 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $66,320
- **Award type:** 1
- **Project period:** 2024-05-31 → 2026-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10952452

## Citation

> US National Institutes of Health, RePORTER application 10952452, PA1627: a new regulator of the Type III secretion system (1R03AI185654-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10952452. Licensed CC0.

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