# Platinum Based Countermeasures and Combinations with Protective Agents

> **NIH NIH UG3** · PURDUE UNIVERSITY · 2024 · $590,302

## Abstract

ABSTRACT
This project's primary endpoint focus will be efficiently rescuing toxic cyanide exposure using three distinct animal
models. None of the current countermeasure options meet the requirements for the risk scenarios and objectives
in PAR 22-209. There are continual threats of chemical exposure to human populations. Health and safety
measures in the workplace cannot fully mitigate the chances of unexpected or malicious use of chemical
toxicants. Safe and effective countermeasures to a cyanide chemical exposures that can deploy in a variety of
challenging emergency settings represent a continual unmet medical need. In addition to survival, mitigating the
sequel morbidities of toxic chemical exposures means another challenge for next-generation countermeasures.
For metabolic poisons that reach high levels of exposure like cyanide, approaches to reverse the insult's effects
are warranted to mitigate more prolonged-term effects. A team of investigators with experience in discovering
and developing countermeasures and therapeutic agents and expertise in medicinal chemistry, pharmacology,
toxicology, discovery pharmaceutics, in vivo phenotypic screens, and complimentary animal models will pursue
milestones established from 3 specific aims. Aim 1: To improve and down-select next-generation platinum (II)-
based countermeasure agents hydrogen cyanide scavengers with properties that meet the criteria for
developability. Aim 2: To evaluate combinations of the metabolite glyoxylate with platinum (II)-based scavenger
agents. Aim 3: To evaluate the efficacy and safety in a porcine model for cyanide intoxication of lead candidate
platinum (II)-based agents alone and in combinations with the metabolite glyoxylate.

## Key facts

- **NIH application ID:** 10953968
- **Project number:** 1UG3NS134957-01A1
- **Recipient organization:** PURDUE UNIVERSITY
- **Principal Investigator:** Vincent Jo Davisson
- **Activity code:** UG3 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $590,302
- **Award type:** 1
- **Project period:** 2024-08-20 → 2026-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10953968

## Citation

> US National Institutes of Health, RePORTER application 10953968, Platinum Based Countermeasures and Combinations with Protective Agents (1UG3NS134957-01A1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10953968. Licensed CC0.

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