# TREAT AD Structural Biology Core

> **NIH NIH U54** · EMORY UNIVERSITY · 2024 · $1,401,940

## Abstract

PROJECT SUMMARY STRUCTURAL BIOLOGY CORE
The Emory-Sage-SGC-Jax TREAT-AD Center Structural Biology (Struc Bio) Core, led by MPI Dr. Aled
Edwards, aims to provide Target Enabling Packages (TEPs): a combination of experimental tools and
knowledge that will allow researchers to investigate the biology of potential AD drug targets and to test
therapeutic hypotheses. The TEPs will consist of: gene knockout reagents and cell lines; purified target
proteins for functional studies and for the development of antibodies and inhibitors; and structures of proteins
and protein:ligand complexes, to understand protein functions and support drug development. Target selection
and the definition of the required experimental tools will be determined in consultation with the Bioinformatics
and the Admin and Data Cores. The Structural Biology Core will have a central role within the Center,
providing purified proteins for assay development and screening by the Medicinal Chemistry and Assay Core
and structural data to guide chemical development by the Medicinal Chemistry Core. By releasing all
reagents and data, we will enable and promote deeper and wider study by the biomedical research community.
The specific aims of the StrucBio Core are:
 1. Identify selective and potent antibodies to aid in target characterization.
 2. Express and purify recombinant target proteins.
 3. To characterize small molecule screening hits.
 4. Generate high-resolution structures of the proteins with small molecules bound.

## Key facts

- **NIH application ID:** 10954114
- **Project number:** 2U54AG065187-06
- **Recipient organization:** EMORY UNIVERSITY
- **Principal Investigator:** ALLAN I LEVEY
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $1,401,940
- **Award type:** 2
- **Project period:** 2019-09-30 → 2029-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10954114

## Citation

> US National Institutes of Health, RePORTER application 10954114, TREAT AD Structural Biology Core (2U54AG065187-06). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10954114. Licensed CC0.

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