ABSTRACT The scale and scope of scientific collaborations in the Human Islet Research Network (HIRN) bring together extraordinary resources to solve complex problems in type 1 diabetes (T1D). To capitalize on this initiative, extensive efforts are required to coordinate, communicate, and catalyze research effectively. The City of Hope is applying to renew the Human Islet Research Enhancement Center (HIREC), providing the administrative and scientific infrastructure needed for day-to-day operations of the HIRN and capitalizing on existing and emerging resources to propel it forward as an innovative team science engine in T1D research. The specific aims of this project were formed to address critical challenges and requirements, or put simply to engineer, enrich, and empower the future of HIRN. The established team is not only experienced in establishing data centers, systems, and resource distribution networks critical to the HIRN, but also are researchers with expertise in T1D disease pathogenesis, biostatistics, bioinformatics, computational biology, data science, semantic technologies, software development, and the use of Findable, Accessible, Interoperable, and Reusable (FAIR) principles. Discoveries arising from HIRN will profoundly improve our understanding of T1D pathogenesis and expedite the advancement of disease prevention and treatment strategies.