The purpose of this administra�ve supplement is to request funds to purchase the latest version of CLAMS Comprehensive lab animal system, which will further improve the services provided by Integrated Physiology of Aging Core (IPAC) of the Nathan Shock Center (NSC) in San Antonio. The IPA core has been a part of the NSC for more than 29 years to support the overall mission of the San Antonio Nathan Shock Center to enable research that aims to expand our understanding of mechanisms of aging and of age-associated disease. The IPA core will provide intellectual and instrumental/technical services to the scien�fic community on the selec�on and performance of func�onal assays in rodents that aim to increase our knowledge about mechanisms that control age-related changes in func�on at the �ssue, organ, and whole-body levels, in the context of normal aging and in rela�on to age-related diseases. We provide exper�se and assistance to inves�gators with an interest in aging-related ques�ons in the design and execu�on, as well as data analysis and interpreta�on on experimental measures. Of all the services offered, the metabolic analysis of aged mice, in response to therapeu�cal interven�on, is an indispensable component in the IPA core. For the metabolic analysis, a CLAMS Comprehensive lab animal system can be used to monitor water consump�on, food intake, locomotor ac�vity, O2/CO2 and energy expenditure, crucial parameters to represent the healthspan in aged mice. With this key piece of equipment, the service quality in IPA core will be greatly enhanced. Thus, the request for addi�onal new equipment conforms to the stated purpose of suppor�ng and enhancing shared resources and facility for categorical research by a number of inves�gators from different disciplines. The integra�on of the San Antonio IPA Core with other programs to study mechanisms of the aging process has been an obvious benefit to these studies. The incorpora�on of a highly advanced CLAMS Comprehensive lab animal system will allow us to provide service to monitor healthspan in different species during aging and by various interven�ons. Project summary /Abstract