# Feasibility of a music listening intervention for mental health recovery in chronic stroke

> **NIH NIH R34** · NEW YORK UNIVERSITY · 2024 · $706,367

## Abstract

Project Summary
This is a feasibility trial testing music listening as an intervention for mental health recovery after stroke. Stroke 
disproportionally affects older individuals and is the second largest cause of death and the third leading cause 
of disability world-wide, with 75% of survivors suffering from motor impairments and more than 30% suffering 
from mental health problems (Lawrence et al., 2001; Hacket and Pickels, 2014). While worse mental health after 
stroke is related with higher risk of long-term disability and higher mortality rate (Jorgensen et al., 2016; Medeiros 
et al., 2020; Blöchl et al. 2019; Shi et al., 2017), there is a lack of affordable, easy to deliver, and accessible
interventions with minimal side effects that improve mental health in the chronic stage of stroke (Allida et al., 
2020). Intentional music listening (IML) refers to the active practice of listening to music (i.e., paying attention to 
the music without engaging in other activities). IML is one of the most popular leisure activities that people use 
to upregulate their mood (Dingle et al., 2021; Linnemann et al., 2015). In stroke, preliminary studies show that 
IML has the potential to reduce depression and anxiety at the acute stage of stroke (Särkämö et al., 2008, 2014; 
Le Danseur et al., 2019; Baylan et al., 2016). However, these preliminary studies suffer from multiple limitations, 
including small sample sizes and the lack of an objective measure of treatment dose (e.g., time engaged in IML, 
acoustic properties of the music listened to). Therefore, research has yet to provide a neuromechanistic account 
of whether and how IML improves mental health outcomes in stroke. Moreover, there are no studies assessing 
the effects of IML at the chronic stage of stroke, when long-term mental health ailments keep increasing the risk 
of disability and mortality (Jorgensen et al., 2016). Here we propose a feasibility trial testing a remote IML 
intervention in chronic stroke that is guided by the NIH Music-based Intervention Toolkit and that includes an 
objective measure of treatment dose. Our neuromechanistic framework builds connections between clinical and 
basic research and borrows the notion of “enriched environment” from animal models of stroke rehabilitation: 
increased motor, sensory, cognitive, and social contexts promote brain plasticity and recovery after brain injury 
(Matsumori et al., 2006; Söderström et al., 2009; Johansson and Belichenko, 2002). This feasibility trial will pave 
the way for future large-scale clinical trials testing whether and how IML provides an optimal enriched 
environment for mental health recovery in chronic stroke. Across two aims, we develop and test the feasibility of 
the proposed IML intervention for chronic stroke. The studies will help to validate the NIH Music-based 
Intervention Toolkit’s guiding principles and will generate pilot data to design future large-scale clinical trials that 
use IML as an intervent...

## Key facts

- **NIH application ID:** 10973344
- **Project number:** 1R34AT012943-01
- **Recipient organization:** NEW YORK UNIVERSITY
- **Principal Investigator:** Magdalena Fuentes
- **Activity code:** R34 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $706,367
- **Award type:** 1
- **Project period:** 2024-09-11 → 2026-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10973344

## Citation

> US National Institutes of Health, RePORTER application 10973344, Feasibility of a music listening intervention for mental health recovery in chronic stroke (1R34AT012943-01). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10973344. Licensed CC0.

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